Entolimod (CBLB502) Biodefense
Entolimod is in development as a countermeasure against death following total body irradiation. Entolimod is a recombinant protein that acts as an agonist of toll-like receptor 5 (TLR5), an innate immunity receptor. Entolimod activation of TLR5 triggers NF-kB signaling, mobilizing an innate immune response that drives expression of numerous genes, including inhibitors of apoptosis, scavengers of reactive oxygen species, and a spectrum of protective or regenerative cytokines.
Availability: In Development
| Manufacturer |
| Cleveland BioLabs, Inc. |
| Product Name |
| Entolimod (CBLB502) Biodefense |
| Detection Category |
| Radiological/Nuclear |
| Detection Method |
| Medical Countermeasure; |
| Application |
| Personal Protective Equipment; |
| Equipment Type |
| PPE |
| Product Synopsis |
| Entolimod is in development as a countermeasure against death following total body irradiation. Entolimod is a recombinant protein that acts as an agonist of toll-like receptor 5 (TLR5), an innate immunity receptor. Entolimod activation of TLR5 triggers NF-kB signaling, mobilizing an innate immune response that drives expression of numerous genes, including inhibitors of apoptosis, scavengers of reactive oxygen species, and a spectrum of protective or regenerative cytokines. |
| Availability |
| In Development |
| Technology Readiness Level (TRL) |
| 6 |
| User Feedback Sources |
| Indifferent/No user feedback |
| Transportability |
| Pocket Size |
| Operating Time |
| Immediate post-exposure use |
| Training Required |
| <1 hour training |
| Manuals Available |
| Yes |
