Nano–Intelligent Detection System (NIDS®)

Nano–Intelligent Detection System (NIDS®) BioThreat Rapid Assay and Handheld Reader. This platform utilizes Lateral Flow Immunochromatography (LFI) in which capture antibodies are immobilized onto the substrate surface. Liquid sample is introduced onto the card and a wicking process forces a diffusion of the liquid analyte along a path toward interaction between the capture antibody and the analyte. A colorimetric change takes place if the analyte is present. ANP markets a multianalyte LFI strip for screening against several pathogens/toxins assembled in a microarray format. LFI strips are analyzed by inserting into a reader that is colorimetric based. Single target assays and multiplexes in 2-plex, 3-plex, 4-plex, and 5-plex formats are available.

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Availability: Commercially available

Greg Witham
Manager of Business Development and Contracts
greg.witham@anptinc.com
+1 302 283 1730
824 Interchange Boulevard
Newark, DE 19711
USA
Ray Yin
President & Chief Technology Officer
ray.yin@anptinc.com
+1 302 283 1730
www.anptinc.com
Manufacturer
ANP Technologies, Inc.
Product Name
Nano–Intelligent Detection System (NIDS®)
Detection Category
Biological
Detection Principle
Immunological;
Detection Method
Lateral Flow Hand Held Immunoassay;
Application
Detection;Emergency Response;
Product Model Number
SARV
Equipment Type
Instrument
Product Synopsis
Nano–Intelligent Detection System (NIDS®) BioThreat Rapid Assay and Handheld Reader. This platform utilizes Lateral Flow Immunochromatography (LFI) in which capture antibodies are immobilized onto the substrate surface. Liquid sample is introduced onto the card and a wicking process forces a diffusion of the liquid analyte along a path toward interaction between the capture antibody and the analyte. A colorimetric change takes place if the analyte is present. ANP markets a multianalyte LFI strip for screening against several pathogens/toxins assembled in a microarray format. LFI strips are analyzed by inserting into a reader that is colorimetric based. Single target assays and multiplexes in 2-plex, 3-plex, 4-plex, and 5-plex formats are available.
Availability
Commercially available
Technology Readiness Level (TRL)
9
Market Entry Date
2008
User Feedback Sources
DoD
Dimensions
4.6 x 2.3 x 3.7 in (11.7 x 5.7 x 9.4 cm)
Weight
<30 lbs.; 0.73lbs (330g) reader, 10 lbs (4.5 kg) complete kit
Power Requirements
AC/DC Line Power; Alkaline Battery; 5V DC power adapter equipped with type A ‘American’ two-prong plug Rated for input of 100-240VAC, 50/60Hz, 150mA, 3 AA batteries (6 to 7 hours)
Transportability
Handheld
Suggested Routine Maintenance
Removable base for easy cleaning and decontamination after a positive result.
Available Accessories
Comes with 10 assay pairs per system
Data Analysis Support Equipment
PC, NIDS SARIV PC Software & Microsoft Excel
Communications Interface
Mini USB port
Shelf Life
<1 year
Unit Cost
$13,200 - $20,000
Maintenance Cost
$20 - $125 sample cost
Tested For Biological Agents
Protein antigens—either whole cells or protein toxins including B. anthracis (anthrax), S. aureus (SEB), Ricin, F. tularensis (tularemia), Brucella, C. burnetii (Q fever), Botulinum toxin A, Y. pestis (plague), V. cholera (cholera)
Other Biological Targets
Vaccinia, Venezuelan Equine Encephalitis, Salmonella, Listeria, E.coli 0157
Adaptability
Yes; user can add new targets to detector with support
Sample Introduction
Liquid
Sensitivity/Detection Limits
ng; cfu/mL; pfu/mL; LOD for each test assay: Bacillus anthracis—1000 CFU/mL; Botulinum toxin—25 ng/mL; Brucella melitensis—106 CFU/mL; Orthopoxvirus—1E5 PFU/mL; Ricin toxin—12 ng/mL; Yersinia pestis—103 CFU/mL; SEB - 4.5ng/mL. Multiplexing capability using a protein microarray for proteomic applications.
Known Interferents/Inhibitors
NIDS-3000CA tested against comprehensive panel of interfering substances containing 26 substances from both an Interference Material Reference Panel and 16 substances from a Suspicious Powders Reference Material Panel. Dipel caused a slight false positive on the F. tularensis test line.
False Negative Rates
Virtually none due to elimination of the Hook Effect
Start Up Time (From Cold Start To Sample Ready)
15 Seconds
Response Time (Sample Application To Output)
>15 minutes
Total Run Time
15 minutes
Alarm Capability
Yes
Software Control
PC software provided with the system allows users to manage data, update firmware, and change settings using the NIDS standalone reader PC software.
Other Operational Parameters
Lateral Flow Immunochromatography
Training Required
<1 day training
Training Available
Yes
Manuals Available
Yes
Reachback Service
Yes
Warranties
1 year from date of sale
Approved Vendors
Federal Resources
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