Far-infrared or
Terahertz spectroscopy (THz) is a technique that identifies chemicals based on
the interaction of molecules with electromagnetic radiation in the far-infrared
or terahertz region (20-400 cm-1). Molecular absorbances
of far-infrared light cause molecular rotations (similar to microwave
radiation) and can be classified by chemical functional groups. The resulting
THz spectrum produced is characteristic for a given molecule. THz spectra of
pure materials can be searched against reference spectral databases, although
an expert spectroscopist should examine data from any potential unknown
mixtures. One strength THz spectroscopy offers is the ability to differentiate
polymorphic differences readily compared to other optical spectroscopy (MIR,
NIR, UV-Vis) methods. This lends the technique to analysis of pharmaceuticals,
consumer products or any other material that has multiple polymorph forms. The technique is most often used in the
analysis of inorganic and organometallic species, although condensed phase
biological samples have also been investigated with THz spectroscopy. Typically
samples are condensed phase materials, although some specialized systems are
capable of analyzing gases in gas cells. Bench top systems are most common.
Instruments are available from a number of manufacturers.