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Real-time Polymerase Chain Reaction (PCR) amplification is generally regarded as the most sensitive and specific means of detecting potential bio warfare pathogens. Results can usually be obtained in about an hour, including a separate sample preparation step to manually extract DNA signatures prior to PCR analysis. Well-characterized COTS DNA extraction kits are available for rapid extraction (20 to 30 minutes) of target DNA from a variety of complex liquid and solid matrices including food, water, and tissue. Samples are prepared by the end user and the instrument performs PCR amplification of the target sequences. Thermal cycling produces additional copies of target sequences, and the fluorescent levels in the reaction change as additional copies are produced. During thermal cycling, the instrument detects copies of the target sequences by measuring changes in fluorescence.

It should be noted that nucleic acid-based detection devices do not directly detect non-nucleic acid targets such as toxins, as inherent in the technology. However, toxins may be indirectly detected via the presence of residual DNA fragments of the organism used to produce the toxin. Residual DNA fragments from the organism used to produce a toxin are typically present at low levels even in the purest of toxin preparations, and fragments are most likely present in higher concentrations in crude preparations.

Manufacturer
Agilent Technologies (1)
Ansera Analytics (S2) (2)
Bertin Instruments (1)
Biomeme, Inc. (2)
bioMérieux, Inc. (5)
Bioneer (1)
BioRad Laboratories, Inc. (2)
Cepheid (5)
Chemring Detection Systems (1)
GenArraytion, Inc. (92)
Genedrive Diagnostics Ltd. (1)
GeneReach USA (3)
Heal Force Bio-meditech Holdings Limited (1)
Luminex Corporation (2)
LuminUltra Technologies, Ltd (1)
Micronics (1)
Pall Corporation (3)
PositiveID Corporation (3)
Roche Diagnostics Corporation (1)
Tetracore, Inc. (2)
Thermo Fisher Scientific, Inc. (4)
Veredus Laboratories (1)
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Transportability
Pocket Size (34)
Handheld (73)
Person-Portable (16)
Mounted (2)
Benchtop/Fixed (10)
Availability
Commercially Available (121)
Discontinued (11)
In Development (2)
Military Only (1)
Unit Cost
< $100 (90)
$100 - $500 (7)
$1,000 - $5,000 (3)
$5,000 - $10,000 (1)
$10,000 - $20,000 (3)
$20,000 - $50,000 (7)
$50,000 - $100,000 (1)
> $100,000 (1)
N/A (22)
Sample Introduction
Solid (6)
Liquid (125)
Vapor/Gas (1)
Other (3)
Sensitivity / Detection Limit
ppq (1)
cfu/mL (4)
ng (6)
copies/mL (1)
Other (15)
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Applied Biosystems 7500 Fast Real-Time PCR System

Applied Biosystems 7500 Fast Real-Time PCR System

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The Applied Biosystems 7500 Fast Real-Time PCR System is a real-time PCR system which enables high...

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ARIES® M1

ARIES® M1

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The ARIES® M1 is a real time PCR instrument that allows the user to control each aspect of the sampl...

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ATHINA® Identifier

ATHINA® Identifier

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ATHINA® Identifier is a lightweight, robust biological agent identifier able to process samples usin...

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Babesia microti RT-PCR Assay

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BioFire® FilmArray® 2.0

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With single database management of up to 8 instruments per computer, the BioFire® FilmArray® 2.0 can...

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bioMérieux, Inc.

BioFire® FilmArray® Torch is the latest advancement in molecular infectious disease diagnostics. The...

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Biotoxis qPCR Detection Kit

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The Biotoxis kit provides a simple method for detection in air, water, and any biological samples. I...

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Borrelia afzelli RT-PCR Assay

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Real-time PCR primer/probe combination for Borrelia afzelli (FAM). GenArraytion's Bioassays are rea...

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Borrelia garinii RT-PCR Assay

Borrelia garinii RT-PCR Assay

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Real-time PCR primer/probe combination for Borrelia garinii (FAM). GenArraytion's Bioassays are rea...

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Borrelia miyamotoi RT-PCR Assay

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Real-time PCR primer/probe combination for Borrelia miyamoto (FAM). GenArraytion's Bioassays are re...

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CFX Touch Series

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The Bio-Rad CFX Touch is a real-time PCR detection system for use with SYBR dyes or Taqman probes. T...

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Coxiella burnetti RT-PCR Assay

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Real-time PCR primer/probe combination Coxiella burnetti (Cy5). GenArraytion's Bioassays are readil...

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DragonFly

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The MicroFluidic System branch of PositiveID has developed a series of cartridges for biological sam...

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Ehrlichia canis RT-PCR Assay

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Real-time PCR primer/probe combination for Ehrlichia canis (FAM). GenArraytion's Bioassays are read...

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Ehrlichia chaffeensis RT-PCR Assay

Ehrlichia chaffeensis RT-PCR Assay

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Real-time PCR primer/probe combination for Ehrlichia chaffeensis (FAM). GenArraytion's Bioassays ar...

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ExiProgen

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Bioneer's ExiProgen™ is a fully automated system for various scientific purposes in synthetic biolog...

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